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Innovations in Science

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671 grants match your search

  • ALS – Nazem Atassi, M.D., MSSc
    Funded: 12/01/17 through 11/30/19
    Grant Announced: Additional Grants 2017
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “One of the main roadblocks for ALS drug development is the lack of markers that tell us about drug efficacy in patients,...”
     
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  • LEMS - William Atchison, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Lambert-Eaton Myasthenic Syndrome (LEMS)
    “Using a mouse model of LEMS, Atchison will explore the means by which certain types of calcium channel proteins are recr...”
     
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  • ALS - Paul August, Ph.D.
    Grant Announced: Winter 2016
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “Paul August is using novel technology to develop a chip that will facilitate the testing of experimental therapies for A...”
     
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  • Identifying novel SMA-causing variants by NGS sequencing of the SMN1 locus – Matthew Avenarius, PhD
    Funded: 09/01/21 through 08/31/22
    Grant Announced: 2021
    Disease Type: Spinal Muscular Atrophy (SMA)
    “In nearly all cases, the genetic defect is caused by the inheritance of two deleted copies of SMN1, which can rapidly be...”
     
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  • SMA - Tomoyuki Awano, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Spinal Muscular Atrophy (SMA)
    “Using a confocal microscope, Awano views a neuromuscular junction in a mouse gastrocnemius muscle. On the computer monit...”
     
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  • CMT - Elisabetta Babetto, Ph.D.
    Grant Announced: Spring 2014
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Elisabetta Babetto will study whether manipulating the PHR1 protein pathway helps to preserve nerve fibers in mice with ...”
     
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  • Muscle disease - Mariah Baker, Ph.D.
    Grant Announced: Spring 2014
    Disease Type: Becker Muscular Dystrophy (BMD)
    “Mariah Baker will investigate how calcium is released in muscle cells, which may lead to treatment for a variety of diso...”
     
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  • Pompe - Celine Baligand, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Metabolic Myopathies
    “The pre-clinical optimization of new potential treatments and the evaluation of their efficacy and administration routes...”
     
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  • CMT - Robert Baloh, M.D., Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Within the fields of ALS and CMT research, Robert Baloh’s specific focus is on using human genetics as a guide toward ...”
     
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  • OPMD - Ayan Banerjee, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: Oculopharyngeal Muscular Dystrophy (OPMD)
    “Banerjee’s goal is to better understand how the PABN1 protein is regulated, in order to develop a better understanding...”
     
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  • ALS - Ellen Barrett, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “These images show motor nerve terminals in the hind limb of a healthy mouse (left) and that of an ALS-affected mouse (ri...”
     
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  • MM - Antonio Barrientos, PhD
    Funded: 08/01/19 through 07/31/22
    Grant Announced: Summer 2019
    Disease Type: Mitochondrial Myopathies (MM)
    “Better understanding of the cellular and mitochondrial processes leading to COX assembly is expected to have a significa...”
     
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  • Mito. Myopathy - Antoni Barrientos, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Mitochondrial Myopathies (MM)
    “Barrientos, pictured with collaborators Flavia Fontanesi and Jingjing Liu, notes that defects in an enzyme called cytoch...”
     
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  • MM - Antoni Barrientos, Ph.D.
    Grant Announced: Winter 2016
    Disease Type: Mitochondrial Myopathies (MM)
    ““The study of mitochondria is now a very ‘hot issue’ for both basic and clinical research, Antoni Barrientos says....”
     
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  • SMA - Gary Bassell, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: Spinal Muscular Atrophy (SMA)
    ““Our central hypothesis is that SMN protein plays a critical role in facilitating regulation of mRNA transport in moto...”
     
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  • BMD, DMD - Linda Baum, M.D., Ph.D.
    Grant Announced: Winter 2013
    Disease Type: Becker Muscular Dystrophy (BMD)
    ““By using these human muscle cells to screen drug libraries to identify compounds that improve cell function, our aim ...”
     
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  • SMA — Lisa Baumbach, Ph.D.
    Grant Announced: Summer 2011
    Disease Type: Spinal Muscular Atrophy (SMA)
    “Baumbach (front, right) with the other members of the lab team that discovered the X-linked gene for spinal muscular atr...”
     
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  • EDMD — Mary Baylies, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Emery-Dreifuss Muscular Dystrophy (EDMD)
    “Like human muscle fibers, each fiber in a fruit fly (drosophila) is multinucleated and has a distinct size and shape. Un...”
     
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  • PP — Kurt Beam
    Grant Announced: Summer 2010
    Disease Type: Endocrine Myopathies
    “"Our MDA research project, 'voltage sensor for excitation-contraction coupling,' seeks to understand how skeletal muscle...”
     
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  • CCD — Kurt Beam, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Endocrine Myopathies
    “Beam uses electrical equipment to measure currents, and a confocal microscope to measure calcium inside cells.”
     
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  • DMD, BMD - Joseph Beavo, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Recent work from Beavo and others strongly suggests that sildenafil ameliorates much of the dysfunction seen in older md...”
     
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  • Aaron Beedle, Ph.D.
    Funded: 02/01/17 through 01/31/20
    Grant Announced: Winter 2017
    Disease Type: Limb-Girdle Muscular Dystrophy (LGMD)
    “Aaron Beedle and colleagues are working to determine whether drugs that target a common intracellular pathway for cell g...”
     
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  • ALS - Asim Beg, Ph.D.
    Grant Announced: Winter 2016
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    ““The devastating impact that ALS has on patients and their families is a major factor that has inspired me to study th...”
     
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  • Myopathies — Alan Beggs, Ph.D.
    Grant Announced: Summer 2011
    Disease Type: Endocrine Myopathies
    “Alan Beggs and colleagues will identify gene mutations in zebrafish that cause congenital myopathies and will screen peo...”
     
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  • nemaline myopathy - Alan Beggs, Ph.D.
    Grant Announced: Winter 2016
    Disease Type: Endocrine Myopathies
    “Alan Beggs is working to uncover genes that cause nemaline myopathy.”
     
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  • Congenital & Other Myopathies – Alan Beggs, PhD
    Funded: 02/01/19 through 01/31/22
    Grant Announced: Winter 2019
    Disease Type: Congenital Myopathies
    “Alan Beggs, PhD, professor of Pediatrics at Harvard Medical School and director of the Manton Center for Orphan Disease ...”
     
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  • CMT — Bogdan Beirowski, M.D., Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Beirowski is studying the loss of axons in Charcot-Marie-Tooth disease (CMT). (Axons are the long fibers through which n...”
     
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  • CMT – Bogdan Karl Beirowski, MD, PhD
    Funded: 08/01/18 through 07/31/21
    Grant Announced: Summer 2018
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Axon degeneration is a central component of irreversible neurological disability in many neuromuscular diseases. There i...”
     
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  • Clinical Procedures to Support Research (CAPTURE) - Michael Benatar, M.D., Ph.D.
    Funded: 07/01/20 through 06/30/23
    Grant Announced: Summer 2020
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “A holy-grail of physician-investigators engaged in both ALS patient care and research has been the efficient and effecti...”
     
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  • ALS – Michael Benatar, M.D., Ph.D., and Jonathan Katz, M.D.
    Funded: 03/01/17 through 02/28/19
    Grant Announced: Additional Grants 2017
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    ““Integration of a mechanism to collect research-useful data through a clinical workflow within the electronic health r...”
     
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  • ALS — Michael Benatar
    Grant Announced: Summer 2010
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “"MDA funding has been absolutely critical for this study," Benatar said, noting that the "strength" of the study lies in...”
     
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  • DM – Andrew Berglund, Ph.D.
    Funded: 08/01/17 through 07/31/20
    Grant Announced: Summer 2017
    Disease Type: Myotonic Dystrophy (DM)
    “I think the myotonic dystrophy field has made great gains in understanding the mechanisms of this disease, and there a n...”
     
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  • MMD/DM - Andrew Berglund, Ph.D.
    Grant Announced: Spring 2014
    Disease Type: Myotonic Dystrophy (DM)
    “Andrew Berglund is investigating whether changing the shape of abnormal genetic material in type 1 or type 2 MMD can red...”
     
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  • IBM - Sanford Bernstein, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Inclusion-Body Myositis (IBM)
    “Pictured: Sanford Bernstein's lab group at San Diego State University. (Bernstein is standing in the back row, second fr...”
     
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  • DMD/BMD - Harold Bernstein, M.D., Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “(Left) A section of mouse leg muscle shows normal muscle fibers, with muscle cell nuclei shown in blue and aligned prope...”
     
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  • ALS - James Berry, M.D.
    Grant Announced: Winter 2011
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “Berry and colleagues are planning a phase 2 human clinical trial of the experimental drug ISIS-333611 as a follow-on stu...”
     
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  • ALS - François Berthod, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “This image shows mouse nervous system cells cultured in a three-dimensional environment. Motor neurons (red) and Schwann...”
     
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  • DMD — Carmen Bertoni, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Carmen Bertoni, Ph.D., focuses on studying gene-editing strategies for DMD.”
     
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  • DMD/BMD — Carmen Bertoni
    Grant Announced: Summer 2010
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Under the microscope: Cross sections of muscle analyzed for dystrophin, the protein missing but needed in Duchenne muscu...”
     
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  • ALS, CMT - Martha Bhattacharya, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: Amyotrophic Lateral Sclerosis (ALS)
    “The peripheral nervous system of the fruit fly Drosophila melanogaster, shown with synaptic vesicle proteins in green an...”
     
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  • FA - Sanjay Bidichandani, PhD
    Funded: 02/01/19 through 01/31/22
    Grant Announced: Winter 2019
    Disease Type: Friedreich's Ataxia (FA)
    “The mechanism of gene silencing in FA is known as epigenetic silencing. As we dig deeper, we realize that the silencing ...”
     
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  • FA - Sanjay Bidichandani, M.B.B.S., Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Friedreich's Ataxia (FA)
    ““We believe that this project will enhance our understanding of the molecular pathogenesis of Friedreich’s ataxia, a...”
     
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  • Jag1 gene therapy in muscular dystrophies – Stefano Biressi, PhD
    Funded: 09/01/21 through 08/31/22
    Grant Announced: 2021
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Despite the similar initiating cause, DMD patients vary significantly in the progression of the disease. Recent studies ...”
     
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  • FSHD – Adam Bittel, PT, DPT, PhD
    Funded: 06/01/19 through 05/31/21
    Grant Announced: Additional Grants 2019
    Disease Type: Facioscapulohumeral Muscular Dystrophy (FSH, FSHD)
    “We are interested in both understanding how exercise affects skeletal muscle in FSHD and identifying the key cellular ev...”
     
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  • Glucocorticoid receptor and muscle stem cell quiescence – Alexandre Blais, PhD
    Funded: 09/01/21 through 08/31/22
    Grant Announced: 2021
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Although research has revealed a number of desirable properties for donor cells, in particular the ability to return to ...”
     
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  • DD/LGMD - Robert Bloch, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Distal Myopathies
    “As part of their research, Bloch and colleagues will test shortened versions of the dysferlin protein for use in gene th...”
     
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  • FSHD — Gregory Block, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Facioscapulohumeral Muscular Dystrophy (FSH, FSHD)
    “Cells taken from an FSHD patient were coaxed to become early-stage muscle fibers called myotubes. The cells are labeled ...”
     
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  • Nemaline Myopathy – Jordan Blondelle, Ph.D.
    Funded: 08/01/17 through 07/31/20
    Grant Announced: Summer 2017
    Disease Type: Endocrine Myopathies
    “My focus is to better understand the role that Cullin-3-related protein degradation may play in the pathological mechani...”
     
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  • CMT – Alessandra Bolino, PhD
    Funded: 08/01/18 through 07/31/21
    Grant Announced: Summer 2018
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Our research is aimed at unravelling how myelination is regulated in the PNS and how perturbation of these mechanisms ca...”
     
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  • DMD - Justin Boyer, PhD
    Funded: 02/01/19 through 01/31/22
    Grant Announced: Winter 2019
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Our research will help define the role of satellite cells in muscular dystrophy. The findings from our proposed work wil...”
     
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