Innovations in Science

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482 grants match your search

  • DMD/BMD - Harold Bernstein, M.D., Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “(Left) A section of mouse leg muscle shows normal muscle fibers, with muscle cell nuclei shown in blue and aligned prope...”
     
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  • ALS - James Berry, M.D.
    Grant Announced: Winter 2011
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “Berry and colleagues are planning a phase 2 human clinical trial of the experimental drug ISIS-333611 as a follow-on stu...”
     
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  • ALS - François Berthod, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “This image shows mouse nervous system cells cultured in a three-dimensional environment. Motor neurons (red) and Schwann...”
     
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  • DMD — Carmen Bertoni, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Carmen Bertoni, Ph.D., focuses on studying gene-editing strategies for DMD.”
     
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  • DMD/BMD — Carmen Bertoni
    Grant Announced: Summer 2010
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Under the microscope: Cross sections of muscle analyzed for dystrophin, the protein missing but needed in Duchenne muscu...”
     
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  • ALS, CMT - Martha Bhattacharya, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “The peripheral nervous system of the fruit fly Drosophila melanogaster, shown with synaptic vesicle proteins in green an...”
     
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  • FA - Sanjay Bidichandani, M.B.B.S., Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Friedreich's Ataxia (FA)
    ““We believe that this project will enhance our understanding of the molecular pathogenesis of Friedreich’s ataxia, a...”
     
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  • DD/LGMD - Robert Bloch, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Distal Myopathies
    “As part of their research, Bloch and colleagues will test shortened versions of the dysferlin protein for use in gene th...”
     
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  • FSHD — Gregory Block, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Facioscapulohumeral Muscular Dystrophy (FSH, FSHD)
    “Cells taken from an FSHD patient were coaxed to become early-stage muscle fibers called myotubes. The cells are labeled ...”
     
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  • Nemaline Myopathy – Jordan Blondelle, Ph.D.
    Funded: 08/01/17 through 07/31/20
    Grant Announced: Summer 2017
    Disease Type: Endocrine Myopathies
    “My focus is to better understand the role that Cullin-3-related protein degradation may play in the pathological mechani...”
     
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  • DMD/BMD - Andrew Brack, Ph.D.
    Grant Announced: Winter 2011
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Brack studies adult muscle stem cells called "satellite cells," and seeks to determine what role, if any, this type of c...”
     
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  • CMS — Paul Brehm, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Congenital Myasthenic Syndromes (CMS)
    “Brehm and Dr. Mike Linhoff at their array tomography setup, where they are generating high-resolution images of the zebr...”
     
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  • Myofibrillar Myopathy – Robert Bryson-Richardson, Ph.D.
    Funded: 02/01/18 through 01/31/20
    Grant Announced: Winter 2018
    Disease Type: Myofibrillar Myopathies (MFM)
    “We are testing multiple drugs in our animal model,” Robert Bryson-Richardson said. “Some of these, if effective, cou...”
     
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  • ALS - Antonius Bunt
    Funded: 01/01/17 through 07/01/18
    Grant Announced: Additional Grants 2017
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “"This MDA grant is important for moving our IZ10023 platform technology forward, with potential benefits for not only pe...”
     
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  • CMT - Robert Burgess, Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Charcot-Marie-Tooth Disease (CMT)
    “Robert Burgess is interested in developing mouse models of CMT and related neuromuscular disorders, and using these mice...”
     
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  • SMA - Arthur Burghes, Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Spinal Muscular Atrophy
    “Arthur Burghes is working to develop a new technique that will allow scientists to accurately predict the severity of a ...”
     
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  • DMD – Dean Burkin, Ph.D.
    Funded: 08/01/17 through 07/31/20
    Grant Announced: Summer 2017
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “I have received other MDA grants which have been critical to these studies,” Dean Burkin says. “This new grant will ...”
     
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  • DMD/BMD — Dean Burkin, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Becker Muscular Dystrophy (BMD)
    “Burkin is working to test the hypothesis that laminin-111 protein therapy can prevent muscle damage after disease onset ...”
     
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  • LGMD – Michele Calos, Ph.D.
    Grant Announced: Summer 2016
    Disease Type: Limb-Girdle Muscular Dystrophy (LGMD)
    ““We are inspired to study LGMD2B and 2D because we are working with families who have patients with these disorders,...”
     
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  • DMD/BMD — Michele Calos
    Grant Announced: Summer 2010
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Pictured: cross-section of a normal mouse leg muscle that has been stained for dystrophin, the protein missing in Duchen...”
     
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  • CMD — Kevin Campbell, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Congenital Muscular Dystrophy (CMD)
    “Longtime MDA grantee Kevin Campbell says current research aims to identify proteins that contribute to the initiation of...”
     
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  • Periodic Paralysis — Stephen Cannon, M.D., Ph.D.
    Grant Announced: Summer 2011
    Disease Type: Ion Channel Diseases
    ““With years of support,” Cannon said, “our MDA-sponsored work progressed from establishing the functional abnormal...”
     
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  • Periodic Paralysis - Steve Cannon, M.D., Ph.D.
    Grant Announced: Winter 2016
    Disease Type: Endocrine Myopathies
    “Steve Cannon is investigating the mechanistic basis for exercise-induced weakness in periodic paralysis.”
     
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  • FSHD – Joel Chamberlain, Ph.D.
    Grant Announced: Summer 2016
    Disease Type: Facioscapulohumeral Muscular Dystrophy (FSH, FSHD)
    ““Our area of focus is important in achieving a greater understanding of the early changes in muscle resulting from DUX...”
     
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  • DMD/BMD — Jeffrey Chamberlain, Ph.D.
    Grant Announced: Additional Grants 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
     
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  • FSHD — Joel Chamberlain, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Facioscapulohumeral Muscular Dystrophy (FSH, FSHD)
    “Many years of research have led recently to an understanding of the unique series of molecular events necessary to cause...”
     
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  • MM - David Chan, M.D., Ph.D.
    Grant Announced: Spring 2014
    Disease Type: Mitochondrial Myopathies (MM)
    “David Chan will study defects in the behavior of mitochondria, which produce energy in cells, in mice with mitochondrial...”
     
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  • Vijayendran Chandran, Ph.D.
    Grant Announced: Winter 2017
    Disease Type: Friedreich's Ataxia (FA)
    ““Molecular biomarkers are important tools in assessing clinical trial outcomes, measuring disease progression, and eva...”
     
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  • DMD — Tathagata Chaudhuri, Ph.D.
    Grant Announced: Summer 2012
    Disease Type: Becker Muscular Dystrophy (BMD)
    “Adult human stem cells derived from bone marrow are called mesenchymal stem cells, or MSCs. Those pictured above have be...”
     
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  • MMD — Ju Chen
    Grant Announced: Summer 2010
    Disease Type: Myotonic Dystrophy (DM)
    “Voluntary (skeletal) muscle at 100 times magnification.”
     
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  • Muscle Physiology - Elizabeth Chen, Ph.D.
    Grant Announced: Winter 2012
    Disease Type: Congenital Muscular Dystrophy (CMD)
    “Pictured: An immature muscle cell called a myoblast (pseudo-colored in pink) invades a myotube (an aggregation of myobla...”
     
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  • DMD/BMD — Martin Childers, Ph.D.
    Grant Announced: Summer 2011
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Childers and colleagues will derive dystrophin-deficient heart cells from the skin cells of people with Duchenne MD, and...”
     
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  • MG - Premkumar Christadoss, M.B.B.S.
    Grant Announced: Winter 2012
    Disease Type: Myasthenia Gravis (MG)
    “Christadoss is working to find a specific therapy for myasthenia gravis that can induce long-term remission of the disea...”
     
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  • CMD, LGMD - Sebahattin Cirak, M.D.
    Grant Announced: Winter 2013
    Disease Type: Congenital Muscular Dystrophy (CMD)
    “Using the latest sequencing technology, Cirak will study RNA extracted from muscle biopsies of people with CMD or LGMD t...”
     
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  • ALS — Don Cleveland, Ph.D.
    Grant Announced: Summer 2011
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “Cleveland expects his new studies to show “whether any benefit from increased mitochondrial activity is shared among m...”
     
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  • ALS - Don Cleveland, Ph.D.
    Grant Announced: Summer 2015
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “Don Cleveland is working on development and testing of gene silencing therapies targeting genes that drive inherited or ...”
     
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  • DMD — Anne Connolly, M.D.
    Grant Announced: Additional Grants 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Anne Connolly, M.D.”
     
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  • MMD — Thomas Cooper, M.D.
    Grant Announced: Summer 2013
    Disease Type: Myotonic Dystrophy (DM)
    “Mutant accumulated RNA (green) located within nuclei (blue) of heart tissue of a mouse model for type 1 myotonic dystrop...”
     
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  • FA - Giovanni Coppola, M.D.
    Grant Announced: Winter 2011
    Disease Type: Friedreich's Ataxia (FA)
    “Because there are numerous compounds with therapeutic potential for Friedreich's ataxia at the preclinical stage of deve...”
     
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  • OPMD – Anita Corbett, Ph.D.
    Grant Announced: Summer 2016
    Disease Type: Oculopharyngeal Muscular Dystrophy (OPMD)
    ““My specific expertise in the biological area impacted in OPMD was my initial inspiration to study the disease, but no...”
     
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  • DMD/BMD — Dawn Cornelison
    Grant Announced: Summer 2010
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “"My lab works to understand how satellite cells, the stem cells of skeletal muscle, act to efficiently and reproducibly ...”
     
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  • SBMA/ALS — Constanza Cortes, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Spinal-Bulbar Muscular Atrophy (SBMA)
    “Constanza Cortes will study regulators of a cell recycling system that is disrupted in SBMA and ALS.”
     
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  • Manuela Corti, Ph.D.
    Funded: 02/01/17 through 01/31/20
    Grant Announced: Winter 2017
    Disease Type: Friedreich's Ataxia (FA)
    “Manuela Corti aims to optimize gene therapy approaches for replacing frataxin in a mouse model of Friedreich’s ataxia,...”
     
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  • Mitochondrial Myopathy, DMD – Gino Cortopassi, Ph.D.
    Funded: 08/01/17 through 07/31/20
    Grant Announced: Summer 2017
    Disease Type: Mitochondrial Myopathies (MM)
    “We believe that this drug, already approved for use in humans, will cure mitochondrial disease in animals,” Gino Corto...”
     
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  • ALS, IBM - Benoit Coulombe, Ph.D.
    Grant Announced: Winter 2013
    Disease Type: ALS: Amyotrophic Lateral Sclerosis
    “Benoit Coulombe (left) and key collaborators in this MDA project, Philippe Cloutier (center) and Denis Faubert (right), ...”
     
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  • LGMD — Richard Cripps
    Grant Announced: Summer 2010
    Disease Type: Limb-Girdle Muscular Dystrophy (LGMD)
    “In completed studies, Cripps and colleagues observed that fruit flies with flawed Trim32 genes exhibit muscle degenerati...”
     
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  • Muscle disease - Colin Crist, Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Spinal-Bulbar Muscular Atrophy (SBMA)
    “Applications of Colin Crist’s research include development of stem cell based treatments and discovery of modifiers of...”
     
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  • DMD — Rachelle Crosbie-Watson, Ph.D.
    Grant Announced: Summer 2013
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    “Rachelle Crosbie-Watson will test the feasibility of using gene transfer therapy to deliver the gene for the sarcospan p...”
     
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  • DMD, LGMD, CMD – Rachelle Crosbie-Watson, Ph.D.
    Grant Announced: Summer 2016
    Disease Type: Duchenne Muscular Dystrophy (DMD)
    ““For the first time, there are numerous ongoing clinical trials focused on Duchenne muscular dystrophy,” Rachelle Cr...”
     
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  • CMD - Peter Currie, Ph.D.
    Grant Announced: Summer 2015
    Disease Type: Congenital Muscular Dystrophy (CMD)
    “Peter Currie is conducting small molecule screening in live zebrafish larvae to isolate small molecules that can modulat...”
     
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