TDP43 has unexpectedly extensive role
Scientists have found that the protein TDP43 normally influences the synthesis of more than 1,500 other proteins, including itself. Mutations in the gene for TDP43 are a known cause of ALS, and TDP43 is depleted in the nucleus and enriched in the cytoplasm (main cell compartment) in ALS-affected nerve cells, even when no TDP43 mutations exist. Understanding TDP43's many functions is likely to improve understanding of ALS.
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