Amyotrophic Lateral Sclerosis (ALS)

ALS Ice Bucket Challenge Returning This August

FDA Approves Investigational New Drug Application for ALS Cellular Therapy

ALS Research Update: Spring 2015

Understanding the many roads that can lead to amyotrophic lateral sclerosis (ALS) is a painstaking but necessary prerequisite to development of disease-modifying treatments. Recently, several research teams have made contributions to this effort. A 2011 MDA career development grant to Adrian Israelson, who was then at the University of California, San Diego, was crucial to the finding that the MIF protein counteracts the effects of ALS-causing mutations in the SOD1 gene.

ALS: Seven Out of 15 Participants in Neuralstem Trial Judged Responders

Maryland-based biotechnology company Neuralstem announced in a March 12, 2014, press release, that a phase 2 trial of its NSI-566 neural stem cells in 15 people with amyotrophic lateral sclerosis (ALS) has shown that the surgical transplantation procedure and the cells

Dear ALS Community

Genervon's 'Master Regulator' Drug Encourages ALS Community

Biopharmaceutical company Genervon has announced what it considers encouraging  results from a "compassionate use" trial of its experimental drug GM604 in a single patient with advanced  amyotrophic lateral sclerosis (ALS).

ALS Stem Cell Trials Move Forward

Stem cells -- cells at an early stage of development that can mature and fulfill specific roles depending on their environment and signals they receive – have intrigued scientists as a possible treatment for amyotrophic lateral sclerosis (ALS) for several years. Now, two biotechnology companies – BrainStorm Cell Therapeutics and Neuralstem – are reporting encouraging results from ALS clinical trials.

The ALS Association and MDA Team Up to Advance ALS Therapy Concept

Major League Baseball’s Commitment to Fighting ALS and

The ALS Ice Bucket Challenge Spurs Funding

ALS: Mexiletine Helped Muscle Cramps But Did Not Show Other Benefits

ALS - Stanley Appel, M.D.

Stanley Appel, a professor of neurology at Methodist Neurological Institute in Houston, was awarded an MDA research grant totaling $253,800 over three years to study immune mechanisms in amyotrophic lateral sclerosis (ALS). Experiments previously conducted by Appel and colleagues in mice with an ALS-like disorder have shown that the immune system acts to protect nerve cells during the early stages of the disease but that it damages nerve cells in the disorder’s later stages.