Amyotrophic Lateral Sclerosis (ALS)

ALS - Davide Trotti, Ph.D.

Davide Trotti, professor of neuroscience at Thomas Jefferson University in Philadelphia, was awarded an MDA research grant totaling $300,000 over three years to elucidate the mechanisms of ALS (amyotrophic lateral sclerosis) caused by mutations in the C9ORF72 gene. Trotti will study how the accumulation of protein clumps in patients with C9ORF72 ALS may contribute to motor neuron death.

ALS - Justin Ichida, Ph.D.

Justin Ichida, assistant professor in the department of stem cell biology and regenerative medicine at the University of Southern California in Los Angeles, was awarded an MDA research grant to elucidate the mechanisms underlying ALS (amyotrophic lateral sclerosis) caused by mutations in the C9ORF72 gene.

ALS - Jeffrey Rothstein, M.D., Ph.D.

Jeffrey Rothstein, professor of neurology and neuroscience at Johns Hopkins University School of Medicine in Baltimore, was awarded an MDA research grant totaling $300,000 over three years to elucidate the mechanisms underlying ALS (amyotrophic lateral sclerosis) caused by mutations in the C9ORF72 gene. Rothstein will use ALS patient-derived stem cells to investigate the role of nuclear dysfunction in ALS caused by C9ORF72 mutations. The work could uncover novel drug targets for ALS.

ALS - Gary Armstrong, Ph.D.

Gary Armstrong, a senior post-doctoral researcher at Université de Montréal in Quebec, Canada, was awarded a development grant totaling $177,670 over three years to further understanding of the synaptic defects that occur in ALS (amyotrophic lateral sclerosis). Abnormalities arising at the neuromuscular junction occur early in animal models of the disease and very little is known about the role central synaptic defects play in disrupting neuronal communication with the muscular system.

ALS - Rita Sattler, Ph.D.

Rita Sattler, associate professor of neurobiology at Barrow Neurological Institute, Dignity Health – St. Joseph’s Hospital in Phoenix, was awarded an MDA research grant totaling $300,000 over three years to elucidate the mechanisms underlying ALS (amyotrophic lateral sclerosis) caused by mutations in the C9ORF72 gene.

ALS - Angelo Lepore, Ph.D.

Angelo Lepore, assistant professor in the department of neuroscience in Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia, was awarded an MDA research grant totaling $300,000 over three years to examine a new mechanism by which non-nerve cells called astrocytes contribute to motor neuron death in ALS (amyotrophic lateral sclerosis).

ALS - Don Cleveland, Ph.D.

Don Cleveland, distinguished professor and chair in the department of cellular and molecular medicine at the University of California, San Diego, in La Jolla, was awarded an MDA research grant totaling $300,000 over three years to elucidate the mechanisms of ALS (amyotrophic lateral sclerosis) caused by mutations in the Fused in Sarcoma (FUS) gene.

ALS - Haining Zhu, Ph.D.

Haining Zhu, a professor in the department of molecular and cellular biochemistry at the University of Kentucky in Lexington, was awarded an MDA research grant totaling $300,000 over three years to study the underlying mechanisms of ALS (amyotrophic lateral sclerosis) caused by mutations in the Fused in Sarcoma (FUS) gene. Zhu recently has found that the FUS protein in ALS is modified by the addition of a phosphate group — a process called phosphorylation.

MDA Unites with the ALS Community as ALS Ice Bucket Challenge Returns

ALS Ice Bucket Challenge Returning This August

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