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Research Grants

ACTIVE GRANTS, 1999

WISCONSIN

FUNDING PROGRAM LEGEND
(EMG) (GRG) (INT) (RF) (RG) (SG) (DG)	Earmarked Gift Genetics Research Grant Interim Grant Research Fellowship Research Grant Special Grant Research Development Grant

Madison - University of Wisconsin

James Ervasti, Ph.D.
(RG) Cellular function of a-dystroglycan glycoforms
$ 55,000.00	1/1/00 - 12/31/00	Year 2
$ 55,000.00	1/1/01 - 12/31/01	Year 3

Summary: Understanding of the physiologic function of the dystrophin-glycoprotein complex (DGC) is necessary for the rational design of effective therapies for individuals suffering from DGC associated neuromuscular disorders, such as DMD, LGMD and CMD.

Mani S. Mahadevan, M.D.
(RG) Mouse models of the myotonic dystrophy (MMD) mutation
$ 75,000.00	1/1/00 -12/31/00	Year 2
$ 75,000.00	1/1/01 -12/31/01	Year 3

Summary: The aim of this project is to understand how the MMD mutation causes disease in mouse models to develop new therapeutic approaches in MMD.

William A. Mohler, Ph.D.
(DG) Molecular and cellular mechanism of cell fusion
$ 35,000.00	1/1/00 - 12/31/00	Year 2
$ 35,000.00	1/1/01 - 12/31/01	Year 3

Summary: All damaged or diseased human muscle is repaired by cell fusion. The model organism C. elegans will be used to find genes controlling the cell fusion process.

Inna N. Rybakova, Ph.D.
(DG) Structure/function of full-length recombinant dystrophin
$ 35,000.00	7/1/99 - 6/30/00	Year 1
$ 35,000.00	7/1/00 - 6/30/01	Year 2
$ 35,000.00	7/1/01 - 6/30/02	Year 3

Summary: Researchers will study the structure/function of dystrophin and utrophin necessary for the rational design of effective therapies for individuals suffering from associated muscular dystrophies.

Jon A. Wolff, M.D.
(RG) Gene therapy in a hamster model for muscular dystrophy
$ 86,037.00	7/1/99 - 6/30/00	Year 2
$ 89,479.00	7/1/00 - 6/30/01	Year 3

Summary: This project will assess the efficacy of treating Duchenne muscular dystrophy by delivering the normal dystrophin gene to muscle cells via an intravascular route.

Milwaukee - St. Luke's Medical Center

Raghavan Raju, Ph.D.
(DG) Experimental autoimmune myasthenia gravis (MG) in HLA transgenic mice
$ 35,000.00	1/1/00 - 12/31/00	Year 2
$ 35,000.00	1/1/01 - 12/31/01	Year 3

Summary: Researchers will study the immunopathogenesis of MG using a humanized mouse model that transgenically expresses MHC molecules enabling development of therapeutic strategies.

Wauwatosa - Medical College of Wisconsin

Danny Riley, Ph.D.
(RG) Compromised sealing of cell membranes in mdx muscle
$ 44,119.00	1/1/00 - 12/31/00	Year 1
$ 38,530.00	1/1/01 - 12/31/01	Year 2
$ 40,601.00	1/1/02 - 12/31/02	Year 3

Summary: Dystrophin protein is defective or missing in Duchenne muscular dystrophy. Researchers examine a new role for dystrophin to seal tears in muscle cell membranes. When dystrophin is missing, membrane tears may result in extensive fiber damage.

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