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Research Grants

ACTIVE GRANTS, 1999

MISSOURI

FUNDING PROGRAM LEGEND
(EMG) (GRG) (INT) (RF) (RG) (SG) (DG)	Earmarked Gift Genetics Research Grant Interim Grant Research Fellowship Research Grant Special Grant Research Development Grant

Columbia - University of Missouri

Catherine Krull, Ph.D.
(RG) Patterning of muscle precursor cell migration
$ 60,324.00	1/1/00 - 12/31/00	Year 2
$ 60,324.00	1/1/01 - 12/31/01	Year 3

Summary: This proposal will examine the potential roles of a newly-identified family of receptor tyrosine kinases and their ligands in the guidance of muscle precursor cells to their final destinations in the developing limb.

Robert Lim, Ph.D.
(RG) Analysis of myogenesis inhibitory factors
$ 50,000.00	1/1/99 - 6/30/00	Extended

Summary: The process by which skeletal muscle cells decide to stop growing and start forming muscle tissue will be studied in order to find new ways to expand myoblast populations.

(RG) Cell cycle regulators in myogenesis and muscle regeneration
$ 50,022.00	1/1/00 - 12/31/00	Year 1
$ 51,464.00	1/1/01 - 12/31/01	Year 2

Summary: To learn what controls whether muscle stem cells will continue to grow and divide during tissue regeneration or stop dividing and start forming muscle tissues.

St. Louis - Washington University

Richard Bischoff, Ph.D.
(RG) Migration of skeletal muscle satellite cells
$ 62,806.00	1/1/99 - 6/30/00	Extended

Summary: Researchers seek to understand factors that control the movement of myoblasts with the aim of improving their dissemination following implantation during myoblast transfer therapy for inherited myopathies.

R. Mark Grady, M.D.
(RG) Genetic analysis of the dystrobrevins
$ 59,388.00	7/1/99 - 6/30/00	Year 2
$ 60,667.00	7/1/00 - 6/30/01	Year 3

Summary: This project is designed to understand the functions of two proteins called a and b-dystrobrevin and how those functions relate to muscular dystrophy.

Jeff Lichtman, M.D., Ph.D.
(RG) Neuromuscular junction maintenance by muscle fibers
$ 53,411.00	1/1/00 - 12/31/00	Year 3

Summary: Signals passing from muscle to nerve are important in maintaining healthy transmission of nerve impulses to muscle. The aim of this project is to discover ways of strengthening the neuromuscular connection when weakened by disease.

Alan Pestronk, M.D.
(RG) A natural history study of Emery-Dreifuss muscular dystrophy (EDMD)
$ 45,000.00	7/1/99 - 6/30/00	Year 2
$ 45,000.00	7/1/00 - 6/30/01	Year 3

Summary: Researchers will study the patterns of abnormality in strength, joint contractures and heart function in patients with EDMD.

Joshua Sanes, Ph.D.
(RG) Determinants of neuromuscular specificity in mammals
$ 67,355.00	1/1/00 - 12/31/00	Year 3

Summary: Motor axons reinnervate muscles selectively but imperfectly after nerve damage. Researchers hope to uncover the molecular basis of this selectivity so that it can be understood and eventually improved.

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