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Research Grants

ACTIVE GRANTS, 1999

COLORADO

FUNDING PROGRAM LEGEND
(EMG) (GRG) (INT) (RF) (RG) (SG) (DG)	Earmarked Gift Genetics Research Grant Interim Grant Research Fellowship Research Grant Special Grant Research Development Grant

Boulder - University of Colorado

David L. Allen, Ph.D.
(DG)  Molecular genetic analysis of the myosin heavy 
chain family in mouse skeletal muscle
$35,000.00	1/1/00 - 12/31/00	Year 2
$35,000.00	1/1/01 - 12/31/01	Year 3

Summary: There are seven different myosin motors in skeletal muscle, but why? Researchers will use genetic manipulation in the mouse to answer this question. At least two of these show symptoms seen in several skeletal myopathies.

Kevin Jones, Ph.D.
(RG)  Requirements for a neurotrophin in peripheral nerve
$68,040.00	1/1/00 - 12/31/00	Year 2
$71,442.00	1/1/01 - 12/31/01	Year 3

Summary: Researchers propose to use genetic techniques in the mouse to determine the importance and roles of a protein strongly implicated in nerve regeneration.

Bradley Olwin, Ph.D.
(RG)  Role of FGFs in skeletal muscle growth and regeneration
$54,399.00	7/1/99 - 6/30/00	Year 3

Summary: Researchers will identify the factors that control skeletal muscle regeneration. Eventually this information would be used to develop or augment genetic therapies used to treat X-linked myopathies, in particular Duchenne muscular dystrophy.

Denver - University of Colorado

William Betz, Ph.D.
(RG)  Optical and EM monitoring of synaptic vesicle trafficking
$33,480.00	1/1/99 - 6/30/00	Extended

Summary: Novel optical techniques will be used to monitor the movements of synaptic vesicles in nerve terminals under a variety of experimental conditions in order to better understand the signaling mechanisms used by nerves.

John Caldwell, Ph.D.
(RG)  Sodium channel localization in skeletal muscle
$60,000.00	1/1/00 - 12/31/00	Year 2
$60,000.00	1/1/01 - 12/31/01	Year 3

Summary: Sodium channels are membrane proteins that allow calcium ions to pass through which is required for muscle contraction. Molecules will be identified that bind to and localize these channels in the muscle.

Fort Collins - Colorado State University

Kurt Beam, Ph.D.
(RG)  Ryanodine receptor dysfunction in central core disease (CCD)
$68,146.00	1/1/00 - 12/31/00	Year 1
$68,146.00	1/1/01 - 12/31/01	Year 2
$68,146.00	1/1/02 - 12/31/02	Year 3

Summary: Mutations of the ryanodine receptor (RyR) gene cause CCD. This project will analyze calcium movement through normal and CCD-mutated RyRs.

Noreen Reist, Ph.D.
(RG)  Structure/function analysis of s
ynaptotagmin in neurotransmitter release
$55,740.00	7/1/99 - 6/30/00	Year 3

Summary: Researchers will identify and determine some of the molecular interactions mediating neuromuscular transmission.

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