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BUT GIRLS DON'T GET DUCHENNE -- OR DO THEY?
When DMD 'Carriers' Have Trouble of their Own
by Margaret Wahl
Illustrations:
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In normal muscle fibers, all nuclei produce dystrophin. |
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In fibers of most DMD carriers, about half the nuclei produce dystrophin. |
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In fibers of manifesting DMD carriers, few nuclei produce dystrophin. |
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In fibers of boys with DMD, none of the nuclei produce dystrophin. |
| The muscle fibers of manifesting carriers can be saved by two mechanisms: 1) Dystrophin can spread through the fiber and compensate for areas where there are no dystrophin-positive nuclei, or 2) satellite cells can move in with dystrophin-positive nuclei. |
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