CMTX is a subtype of CMT, a genetic, neurological disorder that causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.
CMTX has many of the same symptoms of CMT1 and CMT2 , including muscle weakness and atrophy, and changes in sensation, mostly in the feet, lower legs, hands and forearms.
CMTX is caused by mutations in the gene for connexin 32, which normally codes for a protein located in myelin, the insulating sheath that surrounds nerve fibers.
CMTX has its onset in childhood or adolescence, and progression is generally slow.
CMT research  is focused on exploring the effects of defects in genes related to the peripheral nervous system and devising strategies to combat these effects.