Myoadenylate deaminase deficiency is a metabolic muscle disease that interferes with the muscle cell's processing of adenosine triphosphate (ATP), the major energy molecule of the cell.
The disease may cause exercise intolerance, cramps and muscle pain; although, in many cases, people with deficiencies in this enzyme may experience no symptoms.
Myoadenylate deaminase deficiency is caused by a genetic defect in the myoadenylate deaminase enzyme, which affects the cell's ability to process ATP. For more, see Causes/Inheritance.
The disease has its onset in adulthood and does not progress.
Researchers on metabolic diseases of muscle are making progress on a number of fronts, including: